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High-Affinity Naloxone Binding to Filamin A Prevents Mu Opioid Receptor–Gs Coupling Underlying Opioid Tolerance and Dependence

Ultra-low-dose opioid antagonists enhance opioid analgesia and reduce analgesic tolerance and dependence by preventing a G protein coupling switch (Gi/o to Gs) by the mu opioid receptor (MOR), although the binding site of such ultra-low-dose opioid antagonists was previously unknown. Here we show th...

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Detalles Bibliográficos
Autores principales: Wang, Hoau-Yan, Frankfurt, Maya, Burns, Lindsay H.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212716/
https://www.ncbi.nlm.nih.gov/pubmed/18253501
http://dx.doi.org/10.1371/journal.pone.0001554

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