Combined TLR and CD40 Triggering Induces Potent CD8(+) T Cell Expansion with Variable Dependence on Type I IFN

Toll-like receptors are important in the activation of innate immunity, and CD40 is a molecule critical for many T and B cell responses. Whereas agonists for either pathway have been used as vaccine adjuvants, we show that a combination of Toll-like receptor (TLR)7 and CD40 agonists synergize to sti...

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Detalles Bibliográficos
Autores principales: Ahonen, Cory L., Doxsee, Christie L., McGurran, Sean M., Riter, Tony R., Wade, William F., Barth, Richard J., Vasilakos, John P., Noelle, Randolph J., Kedl, Ross M.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212721/
https://www.ncbi.nlm.nih.gov/pubmed/15007094
http://dx.doi.org/10.1084/jem.20031591

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