Critical Role for Kit-mediated Src Kinase But Not PI 3-Kinase Signaling in Pro T and Pro B Cell Development

The Kit receptor functions in hematopoiesis, lymphocyte development, gastrointestinal tract motility, melanogenesis, and gametogenesis. To investigate the roles of different Kit signaling pathways in vivo, we have generated knock-in mice in which docking sites for PI 3-kinase (Kit(Y719)) or Src kina...

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Detalles Bibliográficos
Autores principales: Agosti, Valter, Corbacioglu, Selim, Ehlers, Imke, Waskow, Claudia, Sommer, Gunhild, Berrozpe, Georgina, Kissel, Holger, Tucker, Christine M., Manova, Katia, Moore, Malcolm A.S., Rodewald, Hans-Reimer, Besmer, Peter
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212729/
https://www.ncbi.nlm.nih.gov/pubmed/15024050
http://dx.doi.org/10.1084/jem.20031983

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