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Lnk Inhibits Tpo–mpl Signaling and Tpo-mediated Megakaryocytopoiesis
Thrombopoietin (Tpo) is the primary cytokine regulating megakaryocyte development and platelet production. Tpo signaling through its receptor, c-mpl, activates multiple pathways including signal transducer and activator of transcription (STAT)3, STAT5, phosphoinositide 3-kinase–Akt, and p42/44 mitog...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2004
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212736/ https://www.ncbi.nlm.nih.gov/pubmed/15337790 http://dx.doi.org/10.1084/jem.20040762 |