Activation of PI3K Is Indispensable for Interleukin 7–mediated Viability, Proliferation, Glucose Use, and Growth of T Cell Acute Lymphoblastic Leukemia Cells

Interleukin (IL)-7 is essential for normal T cell development. Previously, we have shown that IL-7 increases viability and proliferation of T cell acute lymphoblastic leukemia (T-ALL) cells by up-regulating Bcl-2 and down-regulating the cyclin-dependent kinase inhibitor p27(kip1). Here, we examined...

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Detalles Bibliográficos
Autores principales: Barata, Joao T., Silva, Ana, Brandao, Joana G., Nadler, Lee M., Cardoso, Angelo A., Boussiotis, Vassiliki A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212738/
https://www.ncbi.nlm.nih.gov/pubmed/15353558
http://dx.doi.org/10.1084/jem.20040789

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