The Same IκBα Mutation in Two Related Individuals Leads to Completely Different Clinical Syndromes

Both innate and adaptive immune responses are dependent on activation of nuclear factor κB (NF-κB), induced upon binding of pathogen-associated molecular patterns to Toll-like receptors (TLRs). In murine models, defects in NF-κB pathway are often lethal and viable knockout mice have severe immune de...

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Detalles Bibliográficos
Autores principales: Janssen, Riny, van Wengen, Annelies, Hoeve, Marieke A., ten Dam, Monique, van der Burg, Miriam, van Dongen, Jacques, van de Vosse, Esther, van Tol, Maarten, Bredius, Robbert, Ottenhoff, Tom H., Weemaes, Corry, van Dissel, Jaap T., Lankester, Arjan
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212739/
https://www.ncbi.nlm.nih.gov/pubmed/15337789
http://dx.doi.org/10.1084/jem.20040773

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