The PYRIN Connection: Novel Players in Innate Immunity and Inflammation

Periodic fever syndromes (PFSs) comprise a subset of the hereditary autoinflammatory disorders that are defined by recurrent self-resolving attacks of systemic inflammatory reactions in the absence of infection or autoimmunity. Recent advances have led to the discovery that members of a new family o...

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Detalles Bibliográficos
Autores principales: Stehlik, Christian, Reed, John C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212741/
https://www.ncbi.nlm.nih.gov/pubmed/15353551
http://dx.doi.org/10.1084/jem.20032234
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author Stehlik, Christian
Reed, John C.
author_facet Stehlik, Christian
Reed, John C.
author_sort Stehlik, Christian
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description Periodic fever syndromes (PFSs) comprise a subset of the hereditary autoinflammatory disorders that are defined by recurrent self-resolving attacks of systemic inflammatory reactions in the absence of infection or autoimmunity. Recent advances have led to the discovery that members of a new family of genes, the PYRIN family, account for several hereditary PFSs. Here we discuss new insights into the function of PYRIN proteins and the molecular basis of PFSs.
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spelling pubmed-22127412008-03-11 The PYRIN Connection: Novel Players in Innate Immunity and Inflammation Stehlik, Christian Reed, John C. J Exp Med Commentary Periodic fever syndromes (PFSs) comprise a subset of the hereditary autoinflammatory disorders that are defined by recurrent self-resolving attacks of systemic inflammatory reactions in the absence of infection or autoimmunity. Recent advances have led to the discovery that members of a new family of genes, the PYRIN family, account for several hereditary PFSs. Here we discuss new insights into the function of PYRIN proteins and the molecular basis of PFSs. The Rockefeller University Press 2004-09-06 /pmc/articles/PMC2212741/ /pubmed/15353551 http://dx.doi.org/10.1084/jem.20032234 Text en Copyright © 2004, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Stehlik, Christian
Reed, John C.
The PYRIN Connection: Novel Players in Innate Immunity and Inflammation
title The PYRIN Connection: Novel Players in Innate Immunity and Inflammation
title_full The PYRIN Connection: Novel Players in Innate Immunity and Inflammation
title_fullStr The PYRIN Connection: Novel Players in Innate Immunity and Inflammation
title_full_unstemmed The PYRIN Connection: Novel Players in Innate Immunity and Inflammation
title_short The PYRIN Connection: Novel Players in Innate Immunity and Inflammation
title_sort pyrin connection: novel players in innate immunity and inflammation
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212741/
https://www.ncbi.nlm.nih.gov/pubmed/15353551
http://dx.doi.org/10.1084/jem.20032234
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