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Theophylline Restores Histone Deacetylase Activity and Steroid Responses in COPD Macrophages

Chronic obstructive pulmonary disease (COPD) is a common chronic inflammatory disease of the lungs with little or no response to glucocorticoids and a high level of oxidative stress. Histone deacetylase (HDAC) activity is reduced in cells of cigarette smokers, and low concentrations of theophylline...

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Detalles Bibliográficos
Autores principales:	Cosio, Borja G., Tsaprouni, Loukia, Ito, Kazuhiro, Jazrawi, Elen, Adcock, Ian M., Barnes, Peter J.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2004
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212744/ https://www.ncbi.nlm.nih.gov/pubmed/15337792 http://dx.doi.org/10.1084/jem.20040416

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