TACI and BAFF-R mediate isotype switching in B cells

The tumor necrosis factor family members BAFF and APRIL induce Ig isotype switching in human B cells. We analyzed the ability of BAFF and APRIL to induce isotype switching in murine B cells to IgG1, IgA, and IgE. APRIL and BAFF each engage two receptors, transmembrane activator and calcium-modulator...

Descripción completa

Detalles Bibliográficos
Autores principales: Castigli, Emanuela, Wilson, Stephen A., Scott, Sumi, Dedeoglu, Fatma, Xu, Shengli, Lam, Kong-Peng, Bram, Richard J., Jabara, Haifa, Geha, Raif S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212754/
https://www.ncbi.nlm.nih.gov/pubmed/15630136
http://dx.doi.org/10.1084/jem.20032000
_version_ 1782148751772614656
author Castigli, Emanuela
Wilson, Stephen A.
Scott, Sumi
Dedeoglu, Fatma
Xu, Shengli
Lam, Kong-Peng
Bram, Richard J.
Jabara, Haifa
Geha, Raif S.
author_facet Castigli, Emanuela
Wilson, Stephen A.
Scott, Sumi
Dedeoglu, Fatma
Xu, Shengli
Lam, Kong-Peng
Bram, Richard J.
Jabara, Haifa
Geha, Raif S.
author_sort Castigli, Emanuela
collection PubMed
description The tumor necrosis factor family members BAFF and APRIL induce Ig isotype switching in human B cells. We analyzed the ability of BAFF and APRIL to induce isotype switching in murine B cells to IgG1, IgA, and IgE. APRIL and BAFF each engage two receptors, transmembrane activator and calcium-modulator and cytophilin ligand interactor (TACI) and B cell maturation antigen (BCMA), on B cells. In addition, BAFF engages a third receptor on B cells, BAFF-R. To determine the role of these receptors in isotype switching, we examined B cells from mice deficient in TACI, BCMA, and BAFF-R. The results obtained indicate that both TACI and BAFF-R are able to transduce signals that result in isotype switching.
format Text
id pubmed-2212754
institution National Center for Biotechnology Information
language English
publishDate 2005
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-22127542008-03-11 TACI and BAFF-R mediate isotype switching in B cells Castigli, Emanuela Wilson, Stephen A. Scott, Sumi Dedeoglu, Fatma Xu, Shengli Lam, Kong-Peng Bram, Richard J. Jabara, Haifa Geha, Raif S. J Exp Med Brief Definitive Report The tumor necrosis factor family members BAFF and APRIL induce Ig isotype switching in human B cells. We analyzed the ability of BAFF and APRIL to induce isotype switching in murine B cells to IgG1, IgA, and IgE. APRIL and BAFF each engage two receptors, transmembrane activator and calcium-modulator and cytophilin ligand interactor (TACI) and B cell maturation antigen (BCMA), on B cells. In addition, BAFF engages a third receptor on B cells, BAFF-R. To determine the role of these receptors in isotype switching, we examined B cells from mice deficient in TACI, BCMA, and BAFF-R. The results obtained indicate that both TACI and BAFF-R are able to transduce signals that result in isotype switching. The Rockefeller University Press 2005-01-03 /pmc/articles/PMC2212754/ /pubmed/15630136 http://dx.doi.org/10.1084/jem.20032000 Text en Copyright © 2005, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Brief Definitive Report
Castigli, Emanuela
Wilson, Stephen A.
Scott, Sumi
Dedeoglu, Fatma
Xu, Shengli
Lam, Kong-Peng
Bram, Richard J.
Jabara, Haifa
Geha, Raif S.
TACI and BAFF-R mediate isotype switching in B cells
title TACI and BAFF-R mediate isotype switching in B cells
title_full TACI and BAFF-R mediate isotype switching in B cells
title_fullStr TACI and BAFF-R mediate isotype switching in B cells
title_full_unstemmed TACI and BAFF-R mediate isotype switching in B cells
title_short TACI and BAFF-R mediate isotype switching in B cells
title_sort taci and baff-r mediate isotype switching in b cells
topic Brief Definitive Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212754/
https://www.ncbi.nlm.nih.gov/pubmed/15630136
http://dx.doi.org/10.1084/jem.20032000
work_keys_str_mv AT castigliemanuela taciandbaffrmediateisotypeswitchinginbcells
AT wilsonstephena taciandbaffrmediateisotypeswitchinginbcells
AT scottsumi taciandbaffrmediateisotypeswitchinginbcells
AT dedeoglufatma taciandbaffrmediateisotypeswitchinginbcells
AT xushengli taciandbaffrmediateisotypeswitchinginbcells
AT lamkongpeng taciandbaffrmediateisotypeswitchinginbcells
AT bramrichardj taciandbaffrmediateisotypeswitchinginbcells
AT jabarahaifa taciandbaffrmediateisotypeswitchinginbcells
AT geharaifs taciandbaffrmediateisotypeswitchinginbcells

Ejemplares similares