Cargando…
Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope
The proapoptotic activity of the transcription factor p53 critically depends on the phosphorylation of serine 46 (p53S46P). Here, we show that syncytia containing p53S46P could be detected in lymph node biopsies from human immunodeficiency virus (HIV)-1 carriers, in the brain of patients with HIV-1–...
Autores principales: | Perfettini, Jean-Luc, Castedo, Maria, Nardacci, Roberta, Ciccosanti, Fabiola, Boya, Patricia, Roumier, Thomas, Larochette, Nathanael, Piacentini, Mauro, Kroemer, Guido |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2005
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212781/ https://www.ncbi.nlm.nih.gov/pubmed/15642743 http://dx.doi.org/10.1084/jem.20041502 |
Ejemplares similares
-
NF-κB and p53 Are the Dominant Apoptosis-inducing Transcription Factors Elicited by the HIV-1 Envelope
por: Perfettini, Jean-Luc, et al.
Publicado: (2004) -
Human Immunodeficiency Virus 1 Envelope Glycoprotein Complex-Induced Apoptosis Involves Mammalian Target of Rapamycin/Fkbp12-Rapamycin–Associated Protein–Mediated P53 Phosphorylation
por: Castedo, Maria, et al.
Publicado: (2001) -
Syncytial apoptosis signaling network induced by the HIV-1 envelope glycoprotein complex: an overview
por: Nardacci, R, et al.
Publicado: (2015) -
LZAP Inhibits p38 MAPK (p38) Phosphorylation and Activity by Facilitating p38 Association with the Wild-Type p53 Induced Phosphatase 1 (WIP1)
por: An, Hanbing, et al.
Publicado: (2011) -
Mitochondrial Apoptosis and the Peripheral Benzodiazepine Receptor: A Novel Target for Viral and Pharmacological Manipulation
por: Castedo, Maria, et al.
Publicado: (2002)