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Prevention of UV radiation–induced immunosuppression by IL-12 is dependent on DNA repair

The immunostimulatory cytokine IL-12 is able to antagonize immunosuppression induced by solar/ultraviolet (UV) radiation via yet unknown mechanisms. IL-12 was recently found to induce deoxyribonucleic acid (DNA) repair. UV-induced DNA damage is an important molecular trigger for UV-mediated immunosu...

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Detalles Bibliográficos
Autores principales: Schwarz, Agatha, Maeda, Akira, Kernebeck, Kerstin, van Steeg, Harry, Beissert, Stefan, Schwarz, Thomas
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212783/
https://www.ncbi.nlm.nih.gov/pubmed/15657287
http://dx.doi.org/10.1084/jem.20041212