IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

Interleukin (IL)-23 is a heterodimeric cytokine composed of a unique p19 subunit, and a common p40 subunit shared with IL-12. IL-12 is important for the development of T helper (Th)1 cells that are essential for host defense and tumor suppression. In contrast, IL-23 does not promote the development...

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Detalles Bibliográficos
Autores principales: Langrish, Claire L., Chen, Yi, Blumenschein, Wendy M., Mattson, Jeanine, Basham, Beth, Sedgwick, Jonathan D., McClanahan, Terrill, Kastelein, Robert A., Cua, Daniel J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212798/
https://www.ncbi.nlm.nih.gov/pubmed/15657292
http://dx.doi.org/10.1084/jem.20041257

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