IL-12– and IL-23–induced T helper cell subsets: birds of the same feather flock together

Traditionally, CD4(+) T cells have been separated into two different subsets named T helper (Th)1 and Th2. A new IL-23–driven subset of Th cells called Th(IL-17) has now been described. The data suggest that IL-23 plays an important role in the differentiation of autoreactive pathogenic T cells. Whe...

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Detalles Bibliográficos
Autores principales: Bettelli, Estelle, Kuchroo, Vijay K.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212800/
https://www.ncbi.nlm.nih.gov/pubmed/15657286
http://dx.doi.org/10.1084/jem.20042279
Descripción
Sumario:Traditionally, CD4(+) T cells have been separated into two different subsets named T helper (Th)1 and Th2. A new IL-23–driven subset of Th cells called Th(IL-17) has now been described. The data suggest that IL-23 plays an important role in the differentiation of autoreactive pathogenic T cells. Whether these IL-23–induced Th(IL-17) cells are a unique subset or are related to other Th subsets is discussed.

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