IL-12– and IL-23–induced T helper cell subsets: birds of the same feather flock together

Traditionally, CD4(+) T cells have been separated into two different subsets named T helper (Th)1 and Th2. A new IL-23–driven subset of Th cells called Th(IL-17) has now been described. The data suggest that IL-23 plays an important role in the differentiation of autoreactive pathogenic T cells. Whe...

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Detalles Bibliográficos
Autores principales: Bettelli, Estelle, Kuchroo, Vijay K.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212800/
https://www.ncbi.nlm.nih.gov/pubmed/15657286
http://dx.doi.org/10.1084/jem.20042279
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author Bettelli, Estelle
Kuchroo, Vijay K.
author_facet Bettelli, Estelle
Kuchroo, Vijay K.
author_sort Bettelli, Estelle
collection PubMed
description Traditionally, CD4(+) T cells have been separated into two different subsets named T helper (Th)1 and Th2. A new IL-23–driven subset of Th cells called Th(IL-17) has now been described. The data suggest that IL-23 plays an important role in the differentiation of autoreactive pathogenic T cells. Whether these IL-23–induced Th(IL-17) cells are a unique subset or are related to other Th subsets is discussed.
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spelling pubmed-22128002008-03-11 IL-12– and IL-23–induced T helper cell subsets: birds of the same feather flock together Bettelli, Estelle Kuchroo, Vijay K. J Exp Med Commentary Traditionally, CD4(+) T cells have been separated into two different subsets named T helper (Th)1 and Th2. A new IL-23–driven subset of Th cells called Th(IL-17) has now been described. The data suggest that IL-23 plays an important role in the differentiation of autoreactive pathogenic T cells. Whether these IL-23–induced Th(IL-17) cells are a unique subset or are related to other Th subsets is discussed. The Rockefeller University Press 2005-01-17 /pmc/articles/PMC2212800/ /pubmed/15657286 http://dx.doi.org/10.1084/jem.20042279 Text en Copyright © 2005, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Bettelli, Estelle
Kuchroo, Vijay K.
IL-12– and IL-23–induced T helper cell subsets: birds of the same feather flock together
title IL-12– and IL-23–induced T helper cell subsets: birds of the same feather flock together
title_full IL-12– and IL-23–induced T helper cell subsets: birds of the same feather flock together
title_fullStr IL-12– and IL-23–induced T helper cell subsets: birds of the same feather flock together
title_full_unstemmed IL-12– and IL-23–induced T helper cell subsets: birds of the same feather flock together
title_short IL-12– and IL-23–induced T helper cell subsets: birds of the same feather flock together
title_sort il-12– and il-23–induced t helper cell subsets: birds of the same feather flock together
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212800/
https://www.ncbi.nlm.nih.gov/pubmed/15657286
http://dx.doi.org/10.1084/jem.20042279
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