Cargando…

Cooperative Roles of CTLA-4 and Regulatory T Cells in Tolerance to an Islet Cell Antigen

Adoptive transfer of ovalbumin (OVA)-specific T cells from the DO.11 TCR transgenic mouse on a Rag(−/−) background into mice expressing OVA in pancreatic islet cells induces acute insulitis and diabetes only if endogenous lymphocytes, including regulatory T cells, are removed. When wild-type OVA-spe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Eggena, Mark P., Walker, Lucy S.K., Nagabhushanam, Vijaya, Barron, Luke, Chodos, Anna, Abbas, Abul K.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2004
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212810/ https://www.ncbi.nlm.nih.gov/pubmed/15210748 http://dx.doi.org/10.1084/jem.20040124

Ejemplares similares

Antigen-dependent Proliferation of CD4(+) CD25(+) Regulatory T Cells In Vivo
por: Walker, Lucy S.K., et al.
Publicado: (2003)

Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti–CTLA-4 antibodies
por: Peggs, Karl S., et al.
Publicado: (2009)

Treg and CTLA-4: Two intertwining pathways to immune tolerance
por: Walker, Lucy S.K.
Publicado: (2013)

Functional Tolerance is Maintained Despite Proliferation of CD4 T Cells after Encounter with Tissue-derived Antigen
por: Ausubel, Lara J., et al.
Publicado: (2002)

Identification of Regulatory T Cells in Tolerated Allografts
por: Graca, Luis, et al.
Publicado: (2002)

Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease
por: Lohr, Jens, et al.
Publicado: (2006)

CTLA-4 and Autoimmunity: New Twists in the Tale
por: Walker, Lucy S.K.
Publicado: (2015)

TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets
por: Wong, Jamie, et al.
Publicado: (2007)

Intratumoral IL-12 combined with CTLA-4 blockade elicits T cell–mediated glioma rejection
por: vom Berg, Johannes, et al.
Publicado: (2013)

Confusing signals: Recent progress in CTLA-4 biology
por: Walker, Lucy S.K., et al.
Publicado: (2015)

Infectious Tolerance: Human CD25(+) Regulatory T Cells Convey Suppressor Activity to Conventional CD4(+) T Helper Cells
por: Jonuleit, Helmut, et al.
Publicado: (2002)

Recruitment of Foxp3(+) T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor
por: Lee, Iris, et al.
Publicado: (2005)

Cytotoxic T Lymphocyte Antigen 4 (CTLA4) Blockade Accelerates the Acute Rejection of Cardiac Allografts in CD28-deficient Mice: CTLA4 Can Function Independently of CD28
por: Lin, Hua, et al.
Publicado: (1998)

IMMUNOLOGICAL ADJUVANTS AND THE MECHANISM OF CELL COOPERATION
por: Maillard, Jean, et al.
Publicado: (1972)

Cd4(+)Cd25(+) Immune Regulatory Cells Are Required for Induction of Tolerance to Alloantigen via Costimulatory Blockade
por: Taylor, Patricia A., et al.
Publicado: (2001)

Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Can Regulate Dendritic Cell–induced Activation and Cytotoxicity of CD8(+) T Cells Independently of CD4(+)T Cell Help
por: McCoy, Kathy D., et al.
Publicado: (1999)

Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Regulates the Unfolding of Autoimmune Diabetes
por: Lühder, Fred, et al.
Publicado: (1998)

Determinant Spreading of T Helper Cell 2 (Th2) Responses to Pancreatic Islet Autoantigens
por: Tian, Jide, et al.
Publicado: (1997)

CD4(+)FoxP3(+) regulatory T cells confer infectious tolerance in a TGF-β–dependent manner
por: Andersson, John, et al.
Publicado: (2008)

CD4(+) regulatory T cells require CTLA-4 for the maintenance of systemic tolerance
por: Friedline, Randall H., et al.
Publicado: (2009)

CD4(+) regulatory T cells require CTLA-4 for the maintenance of systemic tolerance
por: Friedline, Randall H., et al.
Publicado: (2009)

Immunologic Self-Tolerance Maintained by Cd25(+)Cd4(+)Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4
por: Takahashi, Takeshi, et al.
Publicado: (2000)

CCR4-dependent regulatory T cell function in inflammatory bowel disease
por: Yuan, Qian, et al.
Publicado: (2007)

Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo
por: Yadav, Mahesh, et al.
Publicado: (2012)

Interferon γ Is Required for Activation-induced Death of T Lymphocytes
por: Refaeli, Yosef, et al.
Publicado: (2002)

Unravelling the genetic causes of mosaic islet morphology in congenital hyperinsulinism
por: Houghton, Jayne AL, et al.
Publicado: (2019)

Feedback control of regulatory T cell homeostasis by dendritic cells in vivo
por: Darrasse-Jèze, Guillaume, et al.
Publicado: (2009)

A constant affinity threshold for T cell tolerance
por: Naeher, Dieter, et al.
Publicado: (2007)

INDUCTION OF TOLERANCE TO SHEEP RED BLOOD CELLS
por: Anderson, Traute-Heidi, et al.
Publicado: (1972)

CTLA-4 in Regulatory T Cells for Cancer Immunotherapy
por: Sobhani, Navid, et al.
Publicado: (2021)

Immune Tolerance After Delivery of Dying Cells to Dendritic Cells In Situ
por: Liu, Kang, et al.
Publicado: (2002)

Role of Antigen-Presenting Cells in Mediating Tolerance and Autoimmunity
por: Garza, Kristine M., et al.
Publicado: (2000)

Peripheral Autoantigen Induces Regulatory T Cells that Prevent Autoimmunity
por: Seddon, Benedict, et al.
Publicado: (1999)

NK cells promote transplant tolerance by killing donor antigen-presenting cells
por: Yu, Guang, et al.
Publicado: (2006)

Entry of B Cell Receptor into Signaling Domains Is Inhibited in Tolerant B Cells
por: Weintraub, Bennett C., et al.
Publicado: (2000)

Regulatory T cells inhibit stable contacts between CD4(+) T cells and dendritic cells in vivo
por: Tadokoro, Carlos E., et al.
Publicado: (2006)

Vα14 NK T cell–triggered IFN-γ production by Gr-1(+)CD11b(+) cells mediates early graft loss of syngeneic transplanted islets
por: Yasunami, Yohichi, et al.
Publicado: (2005)

Human Cd25(+)Cd4(+) T Regulatory Cells Suppress Naive and Memory T Cell Proliferation and Can Be Expanded in Vitro without Loss of Function
por: Levings, Megan K., et al.
Publicado: (2001)

B7-1 or B7-2 Is Required to Produce the Lymphoproliferative Phenotype in Mice Lacking Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4)
por: Mandelbrot, Didier A., et al.
Publicado: (1999)

Foxp3(+) regulatory T cells maintain immune homeostasis in the skin
por: Dudda, Jan C., et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_vc901ekanpt16kete4vgbiaa2t