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Differential Requirement for TANK-binding Kinase-1 in Type I Interferon Responses to Toll-like Receptor Activation and Viral Infection

TANK-binding kinase-1 (TBK1) and the inducible IκB kinase (IKK-i) have been shown recently to activate interferon (IFN) regulatory factor-3 (IRF3), the primary transcription factor regulating induction of type I IFNs. Here, we have compared the role and specificity of TBK1 in the type I IFN response...

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Detalles Bibliográficos
Autores principales:	Perry, Andrea K., Chow, Edward K., Goodnough, Julia B., Yeh, Wen-Chen, Cheng, Genhong
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2004
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212814/ https://www.ncbi.nlm.nih.gov/pubmed/15210743 http://dx.doi.org/10.1084/jem.20040528

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