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Heterologous T cell immunity in severe hepatitis C virus infection
Hepatitis C virus (HCV) can cause liver disease of variable severity. Expansion of preexisting memory CD8 T cells by cross-reactivity with a new heterologous virus infection has been shown in mice to shape the repertoire of the primary response and to influence virus-related immunopathology (Selin,...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212827/ https://www.ncbi.nlm.nih.gov/pubmed/15753202 http://dx.doi.org/10.1084/jem.20041058 |
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author | Urbani, Simona Amadei, Barbara Fisicaro, Paola Pilli, Massimo Missale, Gabriele Bertoletti, Antonio Ferrari, Carlo |
author_facet | Urbani, Simona Amadei, Barbara Fisicaro, Paola Pilli, Massimo Missale, Gabriele Bertoletti, Antonio Ferrari, Carlo |
author_sort | Urbani, Simona |
collection | PubMed |
description | Hepatitis C virus (HCV) can cause liver disease of variable severity. Expansion of preexisting memory CD8 T cells by cross-reactivity with a new heterologous virus infection has been shown in mice to shape the repertoire of the primary response and to influence virus-related immunopathology (Selin, L.K. 2004. Immunity. 20:5–16). To determine whether this mechanism can influence the course of HCV infection, we analyzed the features of the HCV-specific CD8 T cell response in eight patients with acute HCV infection, two of whom had a particularly severe illness. Patients with severe hepatitis, but not those with mild disease, showed an extremely vigorous CD8 T cell response narrowly focused on a single epitope (NS3 1073–1081), which cross-reacted with an influenza neuraminidase sequence. Our results suggest that CD8 T cell cross-reactivity influences the severity of the HCV-associated liver pathology and depicts a model of disease induction that may apply to different viral infections. |
format | Text |
id | pubmed-2212827 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-22128272008-03-11 Heterologous T cell immunity in severe hepatitis C virus infection Urbani, Simona Amadei, Barbara Fisicaro, Paola Pilli, Massimo Missale, Gabriele Bertoletti, Antonio Ferrari, Carlo J Exp Med Brief Definitive Report Hepatitis C virus (HCV) can cause liver disease of variable severity. Expansion of preexisting memory CD8 T cells by cross-reactivity with a new heterologous virus infection has been shown in mice to shape the repertoire of the primary response and to influence virus-related immunopathology (Selin, L.K. 2004. Immunity. 20:5–16). To determine whether this mechanism can influence the course of HCV infection, we analyzed the features of the HCV-specific CD8 T cell response in eight patients with acute HCV infection, two of whom had a particularly severe illness. Patients with severe hepatitis, but not those with mild disease, showed an extremely vigorous CD8 T cell response narrowly focused on a single epitope (NS3 1073–1081), which cross-reacted with an influenza neuraminidase sequence. Our results suggest that CD8 T cell cross-reactivity influences the severity of the HCV-associated liver pathology and depicts a model of disease induction that may apply to different viral infections. The Rockefeller University Press 2005-03-07 /pmc/articles/PMC2212827/ /pubmed/15753202 http://dx.doi.org/10.1084/jem.20041058 Text en Copyright © 2005, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Brief Definitive Report Urbani, Simona Amadei, Barbara Fisicaro, Paola Pilli, Massimo Missale, Gabriele Bertoletti, Antonio Ferrari, Carlo Heterologous T cell immunity in severe hepatitis C virus infection |
title | Heterologous T cell immunity in severe hepatitis C virus infection |
title_full | Heterologous T cell immunity in severe hepatitis C virus infection |
title_fullStr | Heterologous T cell immunity in severe hepatitis C virus infection |
title_full_unstemmed | Heterologous T cell immunity in severe hepatitis C virus infection |
title_short | Heterologous T cell immunity in severe hepatitis C virus infection |
title_sort | heterologous t cell immunity in severe hepatitis c virus infection |
topic | Brief Definitive Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212827/ https://www.ncbi.nlm.nih.gov/pubmed/15753202 http://dx.doi.org/10.1084/jem.20041058 |
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