Production of type I interferons: plasmacytoid dendritic cells and beyond

Plasmacytoid dendritic cells (pDCs) are specialized producers of type I interferons (IFNs) that respond to most viruses. Because of their antiviral activity and regulatory functions in innate and adaptive immunity, type I IFNs are important not only for antiviral resistance but also in other types o...

Descripción completa

Detalles Bibliográficos
Autores principales: Asselin-Paturel, Carine, Trinchieri, Giorgio
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212850/
https://www.ncbi.nlm.nih.gov/pubmed/16103406
http://dx.doi.org/10.1084/jem.20051395
Descripción
Sumario:Plasmacytoid dendritic cells (pDCs) are specialized producers of type I interferons (IFNs) that respond to most viruses. Because of their antiviral activity and regulatory functions in innate and adaptive immunity, type I IFNs are important not only for antiviral resistance but also in other types of infections and in immune pathology. Here we discuss recent data that begin to reveal the unique molecular mechanisms underlying the remarkably rapid and efficient type I IFN production by pDCs.

Ejemplares similares