Production of type I interferons: plasmacytoid dendritic cells and beyond

Plasmacytoid dendritic cells (pDCs) are specialized producers of type I interferons (IFNs) that respond to most viruses. Because of their antiviral activity and regulatory functions in innate and adaptive immunity, type I IFNs are important not only for antiviral resistance but also in other types o...

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Detalles Bibliográficos
Autores principales: Asselin-Paturel, Carine, Trinchieri, Giorgio
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212850/
https://www.ncbi.nlm.nih.gov/pubmed/16103406
http://dx.doi.org/10.1084/jem.20051395
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author Asselin-Paturel, Carine
Trinchieri, Giorgio
author_facet Asselin-Paturel, Carine
Trinchieri, Giorgio
author_sort Asselin-Paturel, Carine
collection PubMed
description Plasmacytoid dendritic cells (pDCs) are specialized producers of type I interferons (IFNs) that respond to most viruses. Because of their antiviral activity and regulatory functions in innate and adaptive immunity, type I IFNs are important not only for antiviral resistance but also in other types of infections and in immune pathology. Here we discuss recent data that begin to reveal the unique molecular mechanisms underlying the remarkably rapid and efficient type I IFN production by pDCs.
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spelling pubmed-22128502008-03-11 Production of type I interferons: plasmacytoid dendritic cells and beyond Asselin-Paturel, Carine Trinchieri, Giorgio J Exp Med Commentary Plasmacytoid dendritic cells (pDCs) are specialized producers of type I interferons (IFNs) that respond to most viruses. Because of their antiviral activity and regulatory functions in innate and adaptive immunity, type I IFNs are important not only for antiviral resistance but also in other types of infections and in immune pathology. Here we discuss recent data that begin to reveal the unique molecular mechanisms underlying the remarkably rapid and efficient type I IFN production by pDCs. The Rockefeller University Press 2005-08-15 /pmc/articles/PMC2212850/ /pubmed/16103406 http://dx.doi.org/10.1084/jem.20051395 Text en Copyright © 2005, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Asselin-Paturel, Carine
Trinchieri, Giorgio
Production of type I interferons: plasmacytoid dendritic cells and beyond
title Production of type I interferons: plasmacytoid dendritic cells and beyond
title_full Production of type I interferons: plasmacytoid dendritic cells and beyond
title_fullStr Production of type I interferons: plasmacytoid dendritic cells and beyond
title_full_unstemmed Production of type I interferons: plasmacytoid dendritic cells and beyond
title_short Production of type I interferons: plasmacytoid dendritic cells and beyond
title_sort production of type i interferons: plasmacytoid dendritic cells and beyond
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212850/
https://www.ncbi.nlm.nih.gov/pubmed/16103406
http://dx.doi.org/10.1084/jem.20051395
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