11β-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice

The enzyme 11β–hydroxysteroid dehydrogenase (HSD) type 1 converts inactive cortisone into active cortisol in cells, thereby raising the effective glucocorticoid (GC) tone above serum levels. We report that pharmacologic inhibition of 11β-HSD1 has a therapeutic effect in mouse models of metabolic syn...

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Detalles Bibliográficos
Autores principales: Hermanowski-Vosatka, Anne, Balkovec, James M., Cheng, Kang, Chen, Howard Y., Hernandez, Melba, Koo, Gloria C., Le Grand, Cheryl B., Li, Zhihua, Metzger, Joseph M., Mundt, Steven S., Noonan, Heather, Nunes, Christian N., Olson, Steven H., Pikounis, Bill, Ren, Ning, Robertson, Nancy, Schaeffer, James M., Shah, Kashmira, Springer, Martin S., Strack, Alison M., Strowski, Matthias, Wu, Kenneth, Wu, TsueiJu, Xiao, Jianying, Zhang, Bei B., Wright, Samuel D., Thieringer, Rolf
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212859/
https://www.ncbi.nlm.nih.gov/pubmed/16103409
http://dx.doi.org/10.1084/jem.20050119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212859/
https://www.ncbi.nlm.nih.gov/pubmed/16103409
http://dx.doi.org/10.1084/jem.20050119

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