A severe defect in CRAC Ca(2+) channel activation and altered K(+) channel gating in T cells from immunodeficient patients

Engagement of the TCR triggers sustained Ca(2+) entry through Ca(2+) release-activated Ca(2+) (CRAC) channels, which helps drive gene expression underlying the T cell response to pathogens. The identity and activation mechanism of CRAC channels at a molecular level are unknown. We have analyzed ion...

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Detalles Bibliográficos
Autores principales: Feske, Stefan, Prakriya, Murali, Rao, Anjana, Lewis, Richard S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212870/
https://www.ncbi.nlm.nih.gov/pubmed/16147976
http://dx.doi.org/10.1084/jem.20050687

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212870/
https://www.ncbi.nlm.nih.gov/pubmed/16147976
http://dx.doi.org/10.1084/jem.20050687

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