Contrasting models of promiscuous gene expression by thymic epithelium

Medullary thymic epithelial cells (mTECs) express a broad spectrum of tissue- restricted self-antigens (TRAs), which are required for the development of central tolerance. A new study suggests that TRA expression is a specialized property of terminally differentiated mTECs. However, as discussed her...

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Detalles Bibliográficos
Autores principales: Gillard, Geoffrey O., Farr, Andrew G.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212887/
https://www.ncbi.nlm.nih.gov/pubmed/15983067
http://dx.doi.org/10.1084/jem.20050976
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author Gillard, Geoffrey O.
Farr, Andrew G.
author_facet Gillard, Geoffrey O.
Farr, Andrew G.
author_sort Gillard, Geoffrey O.
collection PubMed
description Medullary thymic epithelial cells (mTECs) express a broad spectrum of tissue- restricted self-antigens (TRAs), which are required for the development of central tolerance. A new study suggests that TRA expression is a specialized property of terminally differentiated mTECs. However, as discussed here, an alternative model—whereby TRA expression is regulated by conserved developmental programs active in developing mTECs—may be equally plausible.
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spelling pubmed-22128872008-03-11 Contrasting models of promiscuous gene expression by thymic epithelium Gillard, Geoffrey O. Farr, Andrew G. J Exp Med Commentary Medullary thymic epithelial cells (mTECs) express a broad spectrum of tissue- restricted self-antigens (TRAs), which are required for the development of central tolerance. A new study suggests that TRA expression is a specialized property of terminally differentiated mTECs. However, as discussed here, an alternative model—whereby TRA expression is regulated by conserved developmental programs active in developing mTECs—may be equally plausible. The Rockefeller University Press 2005-07-04 /pmc/articles/PMC2212887/ /pubmed/15983067 http://dx.doi.org/10.1084/jem.20050976 Text en Copyright © 2005, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Gillard, Geoffrey O.
Farr, Andrew G.
Contrasting models of promiscuous gene expression by thymic epithelium
title Contrasting models of promiscuous gene expression by thymic epithelium
title_full Contrasting models of promiscuous gene expression by thymic epithelium
title_fullStr Contrasting models of promiscuous gene expression by thymic epithelium
title_full_unstemmed Contrasting models of promiscuous gene expression by thymic epithelium
title_short Contrasting models of promiscuous gene expression by thymic epithelium
title_sort contrasting models of promiscuous gene expression by thymic epithelium
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212887/
https://www.ncbi.nlm.nih.gov/pubmed/15983067
http://dx.doi.org/10.1084/jem.20050976
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AT farrandrewg contrastingmodelsofpromiscuousgeneexpressionbythymicepithelium

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