Cargando…

Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn

SAP is an adaptor protein that is expressed in NK and T cells. It is mutated in humans who have X-linked lymphoproliferative (XLP) disease. By interacting with SLAM family receptors, SAP enables tyrosine phosphorylation signaling of these receptors by its ability to recruit the Src-related kinase, F...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bloch-Queyrat, Coralie, Fondanèche, Marie-Claude, Chen, Riyan, Yin, Luo, Relouzat, Francis, Veillette, André, Fischer, Alain, Latour, Sylvain
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2005
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212903/ https://www.ncbi.nlm.nih.gov/pubmed/15998796 http://dx.doi.org/10.1084/jem.20050449

Ejemplares similares

Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product
por: Pasquier, Benoit, et al.
Publicado: (2005)

SLAM Family Receptors Regulate Immunity with and without SAP-related Adaptors
por: Veillette, André
Publicado: (2004)

Tyrosine Phosphorylation of Tau by the Src Family Kinases Lck and Fyn
por: Scales, Timothy ME, et al.
Publicado: (2011)

EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase Cγ, Ca(++), and Erk, leading to granule polarization
por: Pérez-Quintero, Luis-Alberto, et al.
Publicado: (2014)

Signaling for NKT cell development: the SAP–FynT connection
por: Borowski, Christine, et al.
Publicado: (2005)

The Src Family Tyrosine Kinase Fyn Regulates Natural Killer T Cell Development
por: Gadue, Paul, et al.
Publicado: (1999)

The Src-Kinase Fyn is Required for Cocaine-Associated Memory Through Regulation of Tau
por: Li, Hongchun, et al.
Publicado: (2022)

Roles of the Src Tyrosine Kinases Lck and Fyn in Regulating γδTCR Signal Strength
por: Laird, Renee M., et al.
Publicado: (2010)

SRC family kinase FYN promotes the neuroendocrine phenotype and visceral metastasis in advanced prostate cancer
por: Gururajan, Murali, et al.
Publicado: (2015)

Src family kinases Fyn and Lyn are constitutively activated and mediate plasmacytoid dendritic cell responses
por: Dallari, S., et al.
Publicado: (2017)

Targeting Src family kinase member Fyn by Saracatinib attenuated liver fibrosis in vitro and in vivo
por: Du, Guifang, et al.
Publicado: (2020)

The Src-family kinase, Fyn, regulates the activation of phosphatidylinositol 3-kinase in an interleukin 2-responsive T cell line
Publicado: (1994)

Clnk, a Novel Slp-76–Related Adaptor Molecule Expressed in Cytokine-Stimulated Hemopoietic Cells
por: Cao, Ming Yu, et al.
Publicado: (1999)

Src family kinases, adaptor proteins and the actin cytoskeleton in epithelial-to-mesenchymal transition
por: Ortiz, Maria A., et al.
Publicado: (2021)

Differential regulation of T cell antigen responsiveness by isoforms of the src-related tyrosine protein kinase p59fyn
Publicado: (1992)

Dasatinib Inhibits Lyn and Fyn Src-Family Kinases in Mast Cells to Suppress Type I Hypersensitivity in Mice
por: Lee, Dajeong, et al.
Publicado: (2020)

SLAM-SAP-Fyn: Old Players with New Roles in iNKT Cell Development and Function
por: Bahal, Devika, et al.
Publicado: (2019)

Pan-Src kinase inhibitor treatment attenuates diabetic kidney injury via inhibition of Fyn kinase-mediated endoplasmic reticulum stress
por: Dorotea, Debra, et al.
Publicado: (2022)

The Rho guanine nucleotide exchange factor PLEKHG1 is activated by interaction with and phosphorylation by Src family kinase member FYN
por: Nakano, Shun, et al.
Publicado: (2022)

Roles of Raft-Anchored Adaptor Cbp/PAG1 in Spatial Regulation of c-Src Kinase
por: Saitou, Takashi, et al.
Publicado: (2014)

Dopamine D1 receptor-mediated NMDA receptor insertion depends on Fyn but not Src kinase pathway in prefrontal cortical neurons
por: Hu, Jian-Li, et al.
Publicado: (2010)

A new paradigm for regulation of protein phosphatase 2A function via Src and Fyn kinase–mediated tyrosine phosphorylation
por: Sontag, Jean-Marie, et al.
Publicado: (2022)

HCV NS5A Protein Containing Potential Ligands for Both Src Homology 2 and 3 Domains Enhances Autophosphorylation of Src Family Kinase Fyn in B Cells
por: Nakashima, Kenji, et al.
Publicado: (2012)

Fyn Kinase Is Required for Optimal Humoral Responses
por: Chaimowitz, Natalia S., et al.
Publicado: (2013)

Regulation of Fyn Through Translocation of Activated Lck into Lipid Rafts
por: Filipp, Dominik, et al.
Publicado: (2003)

Activation of Src, Fyn and Yes non-receptor tyrosine kinases in keratinocytes expressing human papillomavirus (HPV) type 16 E7 oncoprotein
por: Szalmás, Anita, et al.
Publicado: (2013)

The residue at position 5 of the N-terminal region of Src and Fyn modulates their myristoylation, palmitoylation, and membrane interactions
por: Gottlieb-Abraham, Efrat, et al.
Publicado: (2016)

The Emerging and Diverse Roles of Src-Like Adaptor Proteins in Health and Disease
por: Marton, Nikolett, et al.
Publicado: (2015)

Physical and Functional Association of the Src Family Kinases Fyn and Lyn with the Collagen Receptor Glycoprotein VI-Fc Receptor γ Chain Complex on Human Platelets
por: Ezumi, Yasuharu, et al.
Publicado: (1998)

Mechanisms of disease-modifying effect of saracatinib (AZD0530), a Src/Fyn tyrosine kinase inhibitor, in the rat kainate model of temporal lobe epilepsy
por: Sharma, Shaunik, et al.
Publicado: (2021)

The Fyn–ADAP Axis: Cytotoxicity Versus Cytokine Production in Killer Cells
por: Gerbec, Zachary J., et al.
Publicado: (2015)

Fyn regeneration
por: Short, Ben
Publicado: (2012)

Morphological Differentiation of Oligodendrocytes Requires Activation of Fyn Tyrosine Kinase
por: Osterhout, Donna J., et al.
Publicado: (1999)

Fyn kinase inhibition as a novel therapy for Alzheimer’s disease
por: Nygaard, Haakon B, et al.
Publicado: (2014)

Fyn Tyrosine Kinase as Harmonizing Factor in Neuronal Functions and Dysfunctions
por: Matrone, Carmela, et al.
Publicado: (2020)

SRC-like adaptor protein negatively regulates Wnt signaling in intrahepatic cholangiocarcinoma
por: Wang, Yong, et al.
Publicado: (2019)

Src-Like Adaptor Protein (SLAP) Binds to the Receptor Tyrosine Kinase Flt3 and Modulates Receptor Stability and Downstream Signaling
por: Kazi, Julhash U., et al.
Publicado: (2012)

The Adaptor Protein SAP Directly Associates with CD3ζ Chain and Regulates T Cell Receptor Signaling
por: Proust, Richard, et al.
Publicado: (2012)

Laminin-1 redistributes postsynaptic proteins and requires rapsyn, tyrosine phosphorylation, and Src and Fyn to stably cluster acetylcholine receptors
por: Marangi, P. Angelo, et al.
Publicado: (2002)

Src- and Fyn-dependent apical membrane trafficking events control endothelial lumen formation during vascular tube morphogenesis
por: Kim, Dae Joong, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_nm91rel54qekht638sbccqv5vc