TGF-β–dependent CD103 expression by CD8(+) T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease

Destruction of the host intestinal epithelium by donor effector T cell populations is a hallmark of graft-versus-host disease (GVHD), but the underlying mechanisms remain obscure. We demonstrate that CD8(+) T cells expressing CD103, an integrin conferring specificity for the epithelial ligand E-cadh...

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Detalles Bibliográficos
Autores principales: El-Asady, Riham, Yuan, Rongwen, Liu, Kechang, Wang, Donghua, Gress, Ronald E., Lucas, Philip J., Drachenberg, Cinthia B., Hadley, Gregg A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212926/
https://www.ncbi.nlm.nih.gov/pubmed/15897278
http://dx.doi.org/10.1084/jem.20041044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212926/
https://www.ncbi.nlm.nih.gov/pubmed/15897278
http://dx.doi.org/10.1084/jem.20041044

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