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PU.1 is not strictly required for B cell development and its absence induces a B-2 to B-1 cell switch
In this paper, we describe the unexpected outgrowth of B lineage cells from PU.1(−/−) fetal liver cultures. The cells express all early B cell genes tested, including the putative PU.1 target genes IL-7R and EBF but not B220, and can produce immunoglobulin M. However, we observed a delay in the PU.1...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2005
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212978/ https://www.ncbi.nlm.nih.gov/pubmed/16301746 http://dx.doi.org/10.1084/jem.20051089 |