The many roads to cross-presentation

Cross-presentation of extracellular antigens by MHC class I molecules is required for priming cytotoxic T lymphocytes (CTLs) at locations remote from the site of infection. Various mechanisms have been proposed to explain cross-presentation. One such mechanism involves the fusion of the endoplasmic...

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Detalles Bibliográficos
Autores principales: Groothuis, Tom A.M., Neefjes, Jacques
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212981/
https://www.ncbi.nlm.nih.gov/pubmed/16287713
http://dx.doi.org/10.1084/jem.20051379
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author Groothuis, Tom A.M.
Neefjes, Jacques
author_facet Groothuis, Tom A.M.
Neefjes, Jacques
author_sort Groothuis, Tom A.M.
collection PubMed
description Cross-presentation of extracellular antigens by MHC class I molecules is required for priming cytotoxic T lymphocytes (CTLs) at locations remote from the site of infection. Various mechanisms have been proposed to explain cross-presentation. One such mechanism involves the fusion of the endoplasmic reticulum (ER) with the endosomal-phagosomal system, in which the machinery required for peptide loading of MHC class I molecules is introduced directly into the phagosome. Here, we discuss the evidence for and against the ER-phagosome concept as well as other possible mechanisms of cross-presentation.
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spelling pubmed-22129812008-03-11 The many roads to cross-presentation Groothuis, Tom A.M. Neefjes, Jacques J Exp Med Commentary Cross-presentation of extracellular antigens by MHC class I molecules is required for priming cytotoxic T lymphocytes (CTLs) at locations remote from the site of infection. Various mechanisms have been proposed to explain cross-presentation. One such mechanism involves the fusion of the endoplasmic reticulum (ER) with the endosomal-phagosomal system, in which the machinery required for peptide loading of MHC class I molecules is introduced directly into the phagosome. Here, we discuss the evidence for and against the ER-phagosome concept as well as other possible mechanisms of cross-presentation. The Rockefeller University Press 2005-11-21 /pmc/articles/PMC2212981/ /pubmed/16287713 http://dx.doi.org/10.1084/jem.20051379 Text en Copyright © 2005, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Groothuis, Tom A.M.
Neefjes, Jacques
The many roads to cross-presentation
title The many roads to cross-presentation
title_full The many roads to cross-presentation
title_fullStr The many roads to cross-presentation
title_full_unstemmed The many roads to cross-presentation
title_short The many roads to cross-presentation
title_sort many roads to cross-presentation
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212981/
https://www.ncbi.nlm.nih.gov/pubmed/16287713
http://dx.doi.org/10.1084/jem.20051379
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