Dendritic cell maturation by innate lymphocytes: coordinated stimulation of innate and adaptive immunity

Pathogen recognition by Toll-like receptors (TLRs) on dendritic cells (DCs) leads to DC maturation and the initiation of adaptive immunity. Recent studies have shown that innate lymphocytes—natural killer (NK), natural killer T (NKT), and γδ T cells—also trigger DC maturation. This interaction in tu...

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Detalles Bibliográficos
Autores principales: Münz, Christian, Steinman, Ralph M., Fujii, Shin-ichiro
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213015/
https://www.ncbi.nlm.nih.gov/pubmed/16027234
http://dx.doi.org/10.1084/jem.20050810
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author Münz, Christian
Steinman, Ralph M.
Fujii, Shin-ichiro
author_facet Münz, Christian
Steinman, Ralph M.
Fujii, Shin-ichiro
author_sort Münz, Christian
collection PubMed
description Pathogen recognition by Toll-like receptors (TLRs) on dendritic cells (DCs) leads to DC maturation and the initiation of adaptive immunity. Recent studies have shown that innate lymphocytes—natural killer (NK), natural killer T (NKT), and γδ T cells—also trigger DC maturation. This interaction in turn expands and activates innate lymphocytes and initiates adaptive T cell immunity. Here, we comment on the evidence that these pathways are TLR independent and have the potential to respond to infection, malignancy, and immunotherapy.
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spelling pubmed-22130152008-03-11 Dendritic cell maturation by innate lymphocytes: coordinated stimulation of innate and adaptive immunity Münz, Christian Steinman, Ralph M. Fujii, Shin-ichiro J Exp Med Commentary Pathogen recognition by Toll-like receptors (TLRs) on dendritic cells (DCs) leads to DC maturation and the initiation of adaptive immunity. Recent studies have shown that innate lymphocytes—natural killer (NK), natural killer T (NKT), and γδ T cells—also trigger DC maturation. This interaction in turn expands and activates innate lymphocytes and initiates adaptive T cell immunity. Here, we comment on the evidence that these pathways are TLR independent and have the potential to respond to infection, malignancy, and immunotherapy. The Rockefeller University Press 2005-07-18 /pmc/articles/PMC2213015/ /pubmed/16027234 http://dx.doi.org/10.1084/jem.20050810 Text en Copyright © 2005, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Münz, Christian
Steinman, Ralph M.
Fujii, Shin-ichiro
Dendritic cell maturation by innate lymphocytes: coordinated stimulation of innate and adaptive immunity
title Dendritic cell maturation by innate lymphocytes: coordinated stimulation of innate and adaptive immunity
title_full Dendritic cell maturation by innate lymphocytes: coordinated stimulation of innate and adaptive immunity
title_fullStr Dendritic cell maturation by innate lymphocytes: coordinated stimulation of innate and adaptive immunity
title_full_unstemmed Dendritic cell maturation by innate lymphocytes: coordinated stimulation of innate and adaptive immunity
title_short Dendritic cell maturation by innate lymphocytes: coordinated stimulation of innate and adaptive immunity
title_sort dendritic cell maturation by innate lymphocytes: coordinated stimulation of innate and adaptive immunity
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213015/
https://www.ncbi.nlm.nih.gov/pubmed/16027234
http://dx.doi.org/10.1084/jem.20050810
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AT steinmanralphm dendriticcellmaturationbyinnatelymphocytescoordinatedstimulationofinnateandadaptiveimmunity
AT fujiishinichiro dendriticcellmaturationbyinnatelymphocytescoordinatedstimulationofinnateandadaptiveimmunity

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