Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner

Caspase activation in target cells is a major function of granzyme B (grB) during cytotoxic lymphocyte granule-induced apoptosis. grB-mediated cell death can occur in the absence of active caspases, and the molecular targets responsible for this additional pathway remain poorly defined. Apoptotic pl...

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Detalles Bibliográficos
Autores principales: Sebbagh, Michael, Hamelin, Jocelyne, Bertoglio, Jacques, Solary, Eric, Bréard, Jacqueline
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213043/
https://www.ncbi.nlm.nih.gov/pubmed/15699075
http://dx.doi.org/10.1084/jem.20031877

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213043/
https://www.ncbi.nlm.nih.gov/pubmed/15699075
http://dx.doi.org/10.1084/jem.20031877

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