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Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner
Caspase activation in target cells is a major function of granzyme B (grB) during cytotoxic lymphocyte granule-induced apoptosis. grB-mediated cell death can occur in the absence of active caspases, and the molecular targets responsible for this additional pathway remain poorly defined. Apoptotic pl...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2005
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213043/ https://www.ncbi.nlm.nih.gov/pubmed/15699075 http://dx.doi.org/10.1084/jem.20031877 |