Movies, measurement, and modeling: the three Ms of mechanistic immunology

Immunological phenomena that were once deduced from genetic, biochemical, and in situ approaches are now being witnessed in living color, in three dimensions, and in real time. The information in time-lapse imaging can provide valuable mechanistic insight into a host of processes, from cell migratio...

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Detalles Bibliográficos
Autores principales: Witt, Colleen, Raychaudhuri, Subhadip, Chakraborty, Arup K.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213049/
https://www.ncbi.nlm.nih.gov/pubmed/15728232
http://dx.doi.org/10.1084/jem.20050197
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author Witt, Colleen
Raychaudhuri, Subhadip
Chakraborty, Arup K.
author_facet Witt, Colleen
Raychaudhuri, Subhadip
Chakraborty, Arup K.
author_sort Witt, Colleen
collection PubMed
description Immunological phenomena that were once deduced from genetic, biochemical, and in situ approaches are now being witnessed in living color, in three dimensions, and in real time. The information in time-lapse imaging can provide valuable mechanistic insight into a host of processes, from cell migration to signal transduction. What we need now are methods to quantitate these new visual data and to exploit computational resources and statistical mechanical methods to develop mechanistic models.
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spelling pubmed-22130492008-03-11 Movies, measurement, and modeling: the three Ms of mechanistic immunology Witt, Colleen Raychaudhuri, Subhadip Chakraborty, Arup K. J Exp Med Commentary Immunological phenomena that were once deduced from genetic, biochemical, and in situ approaches are now being witnessed in living color, in three dimensions, and in real time. The information in time-lapse imaging can provide valuable mechanistic insight into a host of processes, from cell migration to signal transduction. What we need now are methods to quantitate these new visual data and to exploit computational resources and statistical mechanical methods to develop mechanistic models. The Rockefeller University Press 2005-02-21 /pmc/articles/PMC2213049/ /pubmed/15728232 http://dx.doi.org/10.1084/jem.20050197 Text en Copyright © 2005, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Witt, Colleen
Raychaudhuri, Subhadip
Chakraborty, Arup K.
Movies, measurement, and modeling: the three Ms of mechanistic immunology
title Movies, measurement, and modeling: the three Ms of mechanistic immunology
title_full Movies, measurement, and modeling: the three Ms of mechanistic immunology
title_fullStr Movies, measurement, and modeling: the three Ms of mechanistic immunology
title_full_unstemmed Movies, measurement, and modeling: the three Ms of mechanistic immunology
title_short Movies, measurement, and modeling: the three Ms of mechanistic immunology
title_sort movies, measurement, and modeling: the three ms of mechanistic immunology
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213049/
https://www.ncbi.nlm.nih.gov/pubmed/15728232
http://dx.doi.org/10.1084/jem.20050197
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