Identifying protein–protein interactions in somatic hypermutation

Somatic hypermutation (SHM) in immunoglobulin genes is required for high affinity antibody–antigen binding. Cultured cell systems, mouse model systems, and human genetic deficiencies have been the key players in identifying likely SHM pathways, whereas “pure” biochemical approaches have been far les...

Descripción completa

Detalles Bibliográficos
Autores principales: Goodman, Myron F., Scharff, Matthew D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213056/
https://www.ncbi.nlm.nih.gov/pubmed/15710655
http://dx.doi.org/10.1084/jem.20050161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213056/
https://www.ncbi.nlm.nih.gov/pubmed/15710655
http://dx.doi.org/10.1084/jem.20050161

Ejemplares similares