Twisting tails exposed: the evidence for TCR conformational change

The mechanism by which the ligand occupancy state of the T cell receptor complex is converted into intracellular signaling information has been a controversial topic. Although the majority of structural studies argue against a conformational change, recent studies support the possibility for such a...

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Detalles Bibliográficos
Autores principales: Levin, Susan E., Weiss, Arthur
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213060/
https://www.ncbi.nlm.nih.gov/pubmed/15728230
http://dx.doi.org/10.1084/jem.20050179
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author Levin, Susan E.
Weiss, Arthur
author_facet Levin, Susan E.
Weiss, Arthur
author_sort Levin, Susan E.
collection PubMed
description The mechanism by which the ligand occupancy state of the T cell receptor complex is converted into intracellular signaling information has been a controversial topic. Although the majority of structural studies argue against a conformational change, recent studies support the possibility for such a change within the CD3 components of the TCR complex. In this commentary, the evidence for TCR conformational change is reviewed and potential mechanisms for its initiation are explored.
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spelling pubmed-22130602008-03-11 Twisting tails exposed: the evidence for TCR conformational change Levin, Susan E. Weiss, Arthur J Exp Med Commentary The mechanism by which the ligand occupancy state of the T cell receptor complex is converted into intracellular signaling information has been a controversial topic. Although the majority of structural studies argue against a conformational change, recent studies support the possibility for such a change within the CD3 components of the TCR complex. In this commentary, the evidence for TCR conformational change is reviewed and potential mechanisms for its initiation are explored. The Rockefeller University Press 2005-02-21 /pmc/articles/PMC2213060/ /pubmed/15728230 http://dx.doi.org/10.1084/jem.20050179 Text en Copyright © 2005, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Levin, Susan E.
Weiss, Arthur
Twisting tails exposed: the evidence for TCR conformational change
title Twisting tails exposed: the evidence for TCR conformational change
title_full Twisting tails exposed: the evidence for TCR conformational change
title_fullStr Twisting tails exposed: the evidence for TCR conformational change
title_full_unstemmed Twisting tails exposed: the evidence for TCR conformational change
title_short Twisting tails exposed: the evidence for TCR conformational change
title_sort twisting tails exposed: the evidence for tcr conformational change
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213060/
https://www.ncbi.nlm.nih.gov/pubmed/15728230
http://dx.doi.org/10.1084/jem.20050179
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