Macrophage fusion: the making of osteoclasts and giant cells

The fusion of cells is a fundamental biological event that is essential for a variety of developmental and homeostatic processes. Fusion is required for the formation of multinucleated osteoclasts and giant cells, although the mechanisms that govern these processes are poorly understood. A new study...

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Detalles Bibliográficos
Autor principal: Vignery, Agnès
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213072/
https://www.ncbi.nlm.nih.gov/pubmed/16061722
http://dx.doi.org/10.1084/jem.20051123
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author Vignery, Agnès
author_facet Vignery, Agnès
author_sort Vignery, Agnès
collection PubMed
description The fusion of cells is a fundamental biological event that is essential for a variety of developmental and homeostatic processes. Fusion is required for the formation of multinucleated osteoclasts and giant cells, although the mechanisms that govern these processes are poorly understood. A new study now reveals an unexpected role for the receptor, dendritic cell–specific transmembrane protein (DC-STAMP), in this process. The potential mechanism by which DC-STAMP governs fusion and the implications of this finding will be discussed.
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spelling pubmed-22130722008-03-11 Macrophage fusion: the making of osteoclasts and giant cells Vignery, Agnès J Exp Med Commentary The fusion of cells is a fundamental biological event that is essential for a variety of developmental and homeostatic processes. Fusion is required for the formation of multinucleated osteoclasts and giant cells, although the mechanisms that govern these processes are poorly understood. A new study now reveals an unexpected role for the receptor, dendritic cell–specific transmembrane protein (DC-STAMP), in this process. The potential mechanism by which DC-STAMP governs fusion and the implications of this finding will be discussed. The Rockefeller University Press 2005-08-01 /pmc/articles/PMC2213072/ /pubmed/16061722 http://dx.doi.org/10.1084/jem.20051123 Text en Copyright © 2005, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Vignery, Agnès
Macrophage fusion: the making of osteoclasts and giant cells
title Macrophage fusion: the making of osteoclasts and giant cells
title_full Macrophage fusion: the making of osteoclasts and giant cells
title_fullStr Macrophage fusion: the making of osteoclasts and giant cells
title_full_unstemmed Macrophage fusion: the making of osteoclasts and giant cells
title_short Macrophage fusion: the making of osteoclasts and giant cells
title_sort macrophage fusion: the making of osteoclasts and giant cells
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213072/
https://www.ncbi.nlm.nih.gov/pubmed/16061722
http://dx.doi.org/10.1084/jem.20051123
work_keys_str_mv AT vigneryagnes macrophagefusionthemakingofosteoclastsandgiantcells

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