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DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis

DAP12 (KARAP) is a transmembrane signaling adaptor for a family of innate immunoreceptors that have been shown to activate granulocytes and monocytes/macrophages, amplifying production of inflammatory cytokines. Contrasting with these data, recent studies suggest that DAP12 signaling has an inhibito...

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Detalles Bibliográficos
Autores principales:	Turnbull, Isaiah R., McDunn, Jonathan E., Takai, Toshiyuki, Townsend, R. Reid, Cobb, J. Perren, Colonna, Marco
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2005
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213081/ https://www.ncbi.nlm.nih.gov/pubmed/16061725 http://dx.doi.org/10.1084/jem.20050986

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