Newly generated CD4 T cells in aged animals do not exhibit age-related defects in response to antigen

Using a T cell receptor transgenic (TCR Tg) mouse model, we have shown that TCR Tg CD4 cells from aged mice retain a naive phenotype, but exhibit reduced proliferation and IL-2 production in response to the antigen compared with cells from young mice. We hypothesize that age-related decreases in T c...

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Detalles Bibliográficos
Autores principales: Haynes, Laura, Eaton, Sheri M., Burns, Eve M., Randall, Troy D., Swain, Susan L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213095/
https://www.ncbi.nlm.nih.gov/pubmed/15781577
http://dx.doi.org/10.1084/jem.20041933

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213095/
https://www.ncbi.nlm.nih.gov/pubmed/15781577
http://dx.doi.org/10.1084/jem.20041933

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