T cell aging: naive but not young

The immune system exhibits profound age-related changes, collectively termed immunosenescence. The most visible of these is the decline in protective immunity, which results from a complex interaction of primary immune defects and compensatory homeostatic mechanisms. The sum of these changes is a dy...

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Detalles Bibliográficos
Autor principal: Nikolich-Žugich, Janko
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213096/
https://www.ncbi.nlm.nih.gov/pubmed/15781575
http://dx.doi.org/10.1084/jem.20050341
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author Nikolich-Žugich, Janko
author_facet Nikolich-Žugich, Janko
author_sort Nikolich-Žugich, Janko
collection PubMed
description The immune system exhibits profound age-related changes, collectively termed immunosenescence. The most visible of these is the decline in protective immunity, which results from a complex interaction of primary immune defects and compensatory homeostatic mechanisms. The sum of these changes is a dysregulation of many processes that normally ensure optimal immune function. Recent advances suggest that old mice can produce fully functional new T cells, opening both intriguing inquiry avenues and raising critical questions to be pursued.
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spelling pubmed-22130962008-03-11 T cell aging: naive but not young Nikolich-Žugich, Janko J Exp Med Commentary The immune system exhibits profound age-related changes, collectively termed immunosenescence. The most visible of these is the decline in protective immunity, which results from a complex interaction of primary immune defects and compensatory homeostatic mechanisms. The sum of these changes is a dysregulation of many processes that normally ensure optimal immune function. Recent advances suggest that old mice can produce fully functional new T cells, opening both intriguing inquiry avenues and raising critical questions to be pursued. The Rockefeller University Press 2005-03-21 /pmc/articles/PMC2213096/ /pubmed/15781575 http://dx.doi.org/10.1084/jem.20050341 Text en Copyright © 2005, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Nikolich-Žugich, Janko
T cell aging: naive but not young
title T cell aging: naive but not young
title_full T cell aging: naive but not young
title_fullStr T cell aging: naive but not young
title_full_unstemmed T cell aging: naive but not young
title_short T cell aging: naive but not young
title_sort t cell aging: naive but not young
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213096/
https://www.ncbi.nlm.nih.gov/pubmed/15781575
http://dx.doi.org/10.1084/jem.20050341
work_keys_str_mv AT nikolichzugichjanko tcellagingnaivebutnotyoung

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