Signaling for NKT cell development: the SAP–FynT connection

New studies demonstrate a critical role for the adaptor protein SAP (SLAM-associated protein) during NKT cell development. By connecting homotypic SLAM family receptor interactions with the FynT Src kinase, SAP may integrate a set of long-standing yet seemingly disparate observations characterizing...

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Detalles Bibliográficos
Autores principales: Borowski, Christine, Bendelac, Albert
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213098/
https://www.ncbi.nlm.nih.gov/pubmed/15781574
http://dx.doi.org/10.1084/jem.20050339
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author Borowski, Christine
Bendelac, Albert
author_facet Borowski, Christine
Bendelac, Albert
author_sort Borowski, Christine
collection PubMed
description New studies demonstrate a critical role for the adaptor protein SAP (SLAM-associated protein) during NKT cell development. By connecting homotypic SLAM family receptor interactions with the FynT Src kinase, SAP may integrate a set of long-standing yet seemingly disparate observations characterizing NKT cell development. In fact, SAP-dependent signaling may underlie the development of multiple unconventional T cell lineages whose thymic selection relies on homotypic interactions between hematopoietic cells.
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spelling pubmed-22130982008-03-11 Signaling for NKT cell development: the SAP–FynT connection Borowski, Christine Bendelac, Albert J Exp Med Commentary New studies demonstrate a critical role for the adaptor protein SAP (SLAM-associated protein) during NKT cell development. By connecting homotypic SLAM family receptor interactions with the FynT Src kinase, SAP may integrate a set of long-standing yet seemingly disparate observations characterizing NKT cell development. In fact, SAP-dependent signaling may underlie the development of multiple unconventional T cell lineages whose thymic selection relies on homotypic interactions between hematopoietic cells. The Rockefeller University Press 2005-03-21 /pmc/articles/PMC2213098/ /pubmed/15781574 http://dx.doi.org/10.1084/jem.20050339 Text en Copyright © 2005, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Borowski, Christine
Bendelac, Albert
Signaling for NKT cell development: the SAP–FynT connection
title Signaling for NKT cell development: the SAP–FynT connection
title_full Signaling for NKT cell development: the SAP–FynT connection
title_fullStr Signaling for NKT cell development: the SAP–FynT connection
title_full_unstemmed Signaling for NKT cell development: the SAP–FynT connection
title_short Signaling for NKT cell development: the SAP–FynT connection
title_sort signaling for nkt cell development: the sap–fynt connection
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213098/
https://www.ncbi.nlm.nih.gov/pubmed/15781574
http://dx.doi.org/10.1084/jem.20050339
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