Structural and kinetic basis for heightened immunogenicity of T cell vaccines

Analogue peptides with enhanced binding affinity to major histocompatibility class (MHC) I molecules are currently being used in cancer patients to elicit stronger T cell responses. However, it remains unclear as to how alterations of anchor residues may affect T cell receptor (TCR) recognition. We...

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Detalles Bibliográficos
Autores principales: Chen, Ji-Li, Stewart-Jones, Guillaume, Bossi, Giovanna, Lissin, Nikolai M., Wooldridge, Linda, Choi, Ed Man Lik, Held, Gerhard, Dunbar, P. Rod, Esnouf, Robert M., Sami, Malkit, Boulter, Jonathan M., Rizkallah, Pierre, Renner, Christoph, Sewell, Andrew, van der Merwe, P. Anton, Jakobsen, Bent K., Griffiths, Gillian, Jones, E. Yvonne, Cerundolo, Vincenzo
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213140/
https://www.ncbi.nlm.nih.gov/pubmed/15837811
http://dx.doi.org/10.1084/jem.20042323

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