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Contribution of DNA polymerase η to immunoglobulin gene hypermutation in the mouse

The mutation pattern of immunoglobulin genes was studied in mice deficient for DNA polymerase η, a translesional polymerase whose inactivation is responsible for the xeroderma pigmentosum variant (XP-V) syndrome in humans. Mutations show an 85% G/C biased pattern, similar to that reported for XP-V p...

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Detalles Bibliográficos
Autores principales:	Delbos, Frédéric, De Smet, Annie, Faili, Ahmad, Aoufouchi, Said, Weill, Jean-Claude, Reynaud, Claude-Agnès
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2005
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213152/ https://www.ncbi.nlm.nih.gov/pubmed/15824086 http://dx.doi.org/10.1084/jem.20050292

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