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γδ T cell–induced hyaluronan production by epithelial cells regulates inflammation

Nonhealing wounds are a major complication of diseases such as diabetes and rheumatoid arthritis. For efficient tissue repair, inflammatory cells must infiltrate into the damaged tissue to orchestrate wound closure. Hyaluronan is involved in the inflammation associated with wound repair and binds th...

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Detalles Bibliográficos
Autores principales: Jameson, Julie M., Cauvi, Gabrielle, Sharp, Leslie L., Witherden, Deborah A., Havran, Wendy L.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213158/
https://www.ncbi.nlm.nih.gov/pubmed/15837812
http://dx.doi.org/10.1084/jem.20042057
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author Jameson, Julie M.
Cauvi, Gabrielle
Sharp, Leslie L.
Witherden, Deborah A.
Havran, Wendy L.
author_facet Jameson, Julie M.
Cauvi, Gabrielle
Sharp, Leslie L.
Witherden, Deborah A.
Havran, Wendy L.
author_sort Jameson, Julie M.
collection PubMed
description Nonhealing wounds are a major complication of diseases such as diabetes and rheumatoid arthritis. For efficient tissue repair, inflammatory cells must infiltrate into the damaged tissue to orchestrate wound closure. Hyaluronan is involved in the inflammation associated with wound repair and binds the surface of leukocytes infiltrating damaged sites. Skin γδ T cells play specialized roles in keratinocyte proliferation during wound repair. Here, we show that γδ T cells are required for hyaluronan deposition in the extracellular matrix (ECM) and subsequent macrophage infiltration into wound sites. We describe a novel mechanism of control in which γδ T cell–derived keratinocyte growth factors induce epithelial cell production of hyaluronan. In turn, hyaluronan recruits macrophages to the site of damage. These results demonstrate a novel function for skin γδ T cells in inflammation and provide a new perspective on T cell regulation of ECM molecules.
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spelling pubmed-22131582008-03-11 γδ T cell–induced hyaluronan production by epithelial cells regulates inflammation Jameson, Julie M. Cauvi, Gabrielle Sharp, Leslie L. Witherden, Deborah A. Havran, Wendy L. J Exp Med Article Nonhealing wounds are a major complication of diseases such as diabetes and rheumatoid arthritis. For efficient tissue repair, inflammatory cells must infiltrate into the damaged tissue to orchestrate wound closure. Hyaluronan is involved in the inflammation associated with wound repair and binds the surface of leukocytes infiltrating damaged sites. Skin γδ T cells play specialized roles in keratinocyte proliferation during wound repair. Here, we show that γδ T cells are required for hyaluronan deposition in the extracellular matrix (ECM) and subsequent macrophage infiltration into wound sites. We describe a novel mechanism of control in which γδ T cell–derived keratinocyte growth factors induce epithelial cell production of hyaluronan. In turn, hyaluronan recruits macrophages to the site of damage. These results demonstrate a novel function for skin γδ T cells in inflammation and provide a new perspective on T cell regulation of ECM molecules. The Rockefeller University Press 2005-04-18 /pmc/articles/PMC2213158/ /pubmed/15837812 http://dx.doi.org/10.1084/jem.20042057 Text en Copyright © 2005, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Jameson, Julie M.
Cauvi, Gabrielle
Sharp, Leslie L.
Witherden, Deborah A.
Havran, Wendy L.
γδ T cell–induced hyaluronan production by epithelial cells regulates inflammation
title γδ T cell–induced hyaluronan production by epithelial cells regulates inflammation
title_full γδ T cell–induced hyaluronan production by epithelial cells regulates inflammation
title_fullStr γδ T cell–induced hyaluronan production by epithelial cells regulates inflammation
title_full_unstemmed γδ T cell–induced hyaluronan production by epithelial cells regulates inflammation
title_short γδ T cell–induced hyaluronan production by epithelial cells regulates inflammation
title_sort γδ t cell–induced hyaluronan production by epithelial cells regulates inflammation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213158/
https://www.ncbi.nlm.nih.gov/pubmed/15837812
http://dx.doi.org/10.1084/jem.20042057
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