Tumor cells convert immature myeloid dendritic cells into TGF-β–secreting cells inducing CD4(+)CD25(+) regulatory T cell proliferation

The mechanisms through which regulatory T cells accumulate in lymphoid organs of tumor-bearing hosts remain elusive. Our experiments indicate that the accumulation of CD4(+)CD25(+) regulatory T cells (T reg cells) expressing FoxP3 and exhibiting immunosuppressive function originates from the prolife...

Descripción completa

Detalles Bibliográficos
Autores principales: Ghiringhelli, François, Puig, Pierre E., Roux, Stephan, Parcellier, Arnaud, Schmitt, Elise, Solary, Eric, Kroemer, Guido, Martin, François, Chauffert, Bruno, Zitvogel, Laurence
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213166/
https://www.ncbi.nlm.nih.gov/pubmed/16186184
http://dx.doi.org/10.1084/jem.20050463

Ejemplares similares

Ejemplares similares