Blocking IL-1 in systemic inflammation

A growing number of systemic inflammatory diseases characterized in part by recurrent fevers, leukocytosis, anemia, and elevated acute phase proteins are linked to interleukin (IL)-1 activity since rapid and sustained resolution is observed upon specific blockade of IL-1 receptors. Rapid resolution...

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Detalles Bibliográficos
Autor principal: Dinarello, Charles A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213199/
https://www.ncbi.nlm.nih.gov/pubmed/15867089
http://dx.doi.org/10.1084/jem.20050640
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author Dinarello, Charles A.
author_facet Dinarello, Charles A.
author_sort Dinarello, Charles A.
collection PubMed
description A growing number of systemic inflammatory diseases characterized in part by recurrent fevers, leukocytosis, anemia, and elevated acute phase proteins are linked to interleukin (IL)-1 activity since rapid and sustained resolution is observed upon specific blockade of IL-1 receptors. Rapid resolution of systemic and local inflammation is now also reported in systemic onset juvenile idiopathic arthritis (SoJIA). Loss of control of the secretion of IL-1β might be a common mechanism explaining the aberrant activity of IL-1 in these diseases.
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spelling pubmed-22131992008-03-11 Blocking IL-1 in systemic inflammation Dinarello, Charles A. J Exp Med Commentary A growing number of systemic inflammatory diseases characterized in part by recurrent fevers, leukocytosis, anemia, and elevated acute phase proteins are linked to interleukin (IL)-1 activity since rapid and sustained resolution is observed upon specific blockade of IL-1 receptors. Rapid resolution of systemic and local inflammation is now also reported in systemic onset juvenile idiopathic arthritis (SoJIA). Loss of control of the secretion of IL-1β might be a common mechanism explaining the aberrant activity of IL-1 in these diseases. The Rockefeller University Press 2005-05-02 /pmc/articles/PMC2213199/ /pubmed/15867089 http://dx.doi.org/10.1084/jem.20050640 Text en Copyright © 2005, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Dinarello, Charles A.
Blocking IL-1 in systemic inflammation
title Blocking IL-1 in systemic inflammation
title_full Blocking IL-1 in systemic inflammation
title_fullStr Blocking IL-1 in systemic inflammation
title_full_unstemmed Blocking IL-1 in systemic inflammation
title_short Blocking IL-1 in systemic inflammation
title_sort blocking il-1 in systemic inflammation
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213199/
https://www.ncbi.nlm.nih.gov/pubmed/15867089
http://dx.doi.org/10.1084/jem.20050640
work_keys_str_mv AT dinarellocharlesa blockingil1insystemicinflammation

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