Deletion of DOCK2, a regulator of the actin cytoskeleton in lymphocytes, suppresses cardiac allograft rejection

Allograft rejection is induced by graft tissue infiltration of alloreactive T cells that are activated mainly in secondary lymphoid organs of the host. DOCK2 plays a critical role in lymphocyte homing and immunological synapse formation by regulating the actin cytoskeleton, yet its role in the in vi...

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Detalles Bibliográficos
Autores principales: Jiang, Hongsi, Pan, Fan, Erickson, Laurie M., Jang, Mei-Shiang, Sanui, Terukazu, Kunisaki, Yuya, Sasazuki, Takehiko, Kobayashi, Masakazu, Fukui, Yoshinori
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213204/
https://www.ncbi.nlm.nih.gov/pubmed/16230477
http://dx.doi.org/10.1084/jem.20050911

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