Fat meets the cholinergic antiinflammatory pathway

The cholinergic antiinflammatory pathway is a neural mechanism that is controlled by the vagus nerve and inhibits local cytokine release, thereby preventing the damaging effects of cytokine overproduction. A new study now shows that dietary fat can activate this pathway, a finding that may help expl...

Descripción completa

Detalles Bibliográficos
Autor principal: Tracey, Kevin J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213208/
https://www.ncbi.nlm.nih.gov/pubmed/16230472
http://dx.doi.org/10.1084/jem.20051760
_version_ 1782148848011968512
author Tracey, Kevin J.
author_facet Tracey, Kevin J.
author_sort Tracey, Kevin J.
collection PubMed
description The cholinergic antiinflammatory pathway is a neural mechanism that is controlled by the vagus nerve and inhibits local cytokine release, thereby preventing the damaging effects of cytokine overproduction. A new study now shows that dietary fat can activate this pathway, a finding that may help explain the immune system's failure to react to food antigens and commensal bacteria. Here we discuss this new data and its potential implications for dietary intervention in the treatment of inflammatory diseases.
format Text
id pubmed-2213208
institution National Center for Biotechnology Information
language English
publishDate 2005
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-22132082008-03-11 Fat meets the cholinergic antiinflammatory pathway Tracey, Kevin J. J Exp Med Commentary The cholinergic antiinflammatory pathway is a neural mechanism that is controlled by the vagus nerve and inhibits local cytokine release, thereby preventing the damaging effects of cytokine overproduction. A new study now shows that dietary fat can activate this pathway, a finding that may help explain the immune system's failure to react to food antigens and commensal bacteria. Here we discuss this new data and its potential implications for dietary intervention in the treatment of inflammatory diseases. The Rockefeller University Press 2005-10-17 /pmc/articles/PMC2213208/ /pubmed/16230472 http://dx.doi.org/10.1084/jem.20051760 Text en Copyright © 2005, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Tracey, Kevin J.
Fat meets the cholinergic antiinflammatory pathway
title Fat meets the cholinergic antiinflammatory pathway
title_full Fat meets the cholinergic antiinflammatory pathway
title_fullStr Fat meets the cholinergic antiinflammatory pathway
title_full_unstemmed Fat meets the cholinergic antiinflammatory pathway
title_short Fat meets the cholinergic antiinflammatory pathway
title_sort fat meets the cholinergic antiinflammatory pathway
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213208/
https://www.ncbi.nlm.nih.gov/pubmed/16230472
http://dx.doi.org/10.1084/jem.20051760
work_keys_str_mv AT traceykevinj fatmeetsthecholinergicantiinflammatorypathway

Ejemplares similares