Cargando…
CD4(+)CD25(+) regulatory T cells inhibit natural killer cell functions in a transforming growth factor–β–dependent manner
Tumor growth promotes the expansion of CD4(+)CD25(+) regulatory T (T reg) cells that counteract T cell–mediated immune responses. An inverse correlation between natural killer (NK) cell activation and T reg cell expansion in tumor-bearing patients, shown here, prompted us to address the role of T re...
Autores principales: | Ghiringhelli, François, Ménard, Cédric, Terme, Magali, Flament, Caroline, Taieb, Julien, Chaput, Nathalie, Puig, Pierre E., Novault, Sophie, Escudier, Bernard, Vivier, Eric, Lecesne, Axel, Robert, Caroline, Blay, Jean-Yves, Bernard, Jacky, Caillat-Zucman, Sophie, Freitas, Antonio, Tursz, Thomas, Wagner-Ballon, Orianne, Capron, Claude, Vainchencker, William, Martin, François, Zitvogel, Laurence |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2005
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213209/ https://www.ncbi.nlm.nih.gov/pubmed/16230475 http://dx.doi.org/10.1084/jem.20051511 |
Ejemplares similares
-
Dendritic Cell-Derived Exosomes Promote Natural Killer Cell Activation and Proliferation: A Role for NKG2D Ligands and IL-15Rα
por: Viaud, Sophie, et al.
Publicado: (2009) -
Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial
por: Escudier, Bernard, et al.
Publicado: (2005) -
Dendritic Cell Maturation Overrules H-2d–Mediated Natural Killer T (Nkt) Cell Inhibition: Critical Role for B7 in Cd1d-Dependent Nkt Cell Interferon γ Production
por: Ikarashi, Yoshinori, et al.
Publicado: (2001) -
Tumor cells convert immature myeloid dendritic cells into TGF-β–secreting cells inducing CD4(+)CD25(+) regulatory T cell proliferation
por: Ghiringhelli, François, et al.
Publicado: (2005) -
Control of NK Cell Activation by Immune Checkpoint Molecules
por: Beldi-Ferchiou, Asma, et al.
Publicado: (2017)