Notch signaling is an important regulator of type 2 immunity

Notch ligands and receptors have been implicated in helper T cell (Th cell) differentiation. Whether Notch signals are involved in differentiation of T helper type 1 (Th1) cells, Th2 cells, or both, however, remains unresolved. To clarify the role of Notch in Th cell differentiation, we generated mi...

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Detalles Bibliográficos
Autores principales: Tu, LiLi, Fang, Terry C., Artis, David, Shestova, Olga, Pross, Seth E., Maillard, Ivan, Pear, Warren S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213210/
https://www.ncbi.nlm.nih.gov/pubmed/16230473
http://dx.doi.org/10.1084/jem.20050923
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author Tu, LiLi
Fang, Terry C.
Artis, David
Shestova, Olga
Pross, Seth E.
Maillard, Ivan
Pear, Warren S.
author_facet Tu, LiLi
Fang, Terry C.
Artis, David
Shestova, Olga
Pross, Seth E.
Maillard, Ivan
Pear, Warren S.
author_sort Tu, LiLi
collection PubMed
description Notch ligands and receptors have been implicated in helper T cell (Th cell) differentiation. Whether Notch signals are involved in differentiation of T helper type 1 (Th1) cells, Th2 cells, or both, however, remains unresolved. To clarify the role of Notch in Th cell differentiation, we generated mice that conditionally inactivate Notch signaling in mature T cells. Mice that lack Notch signaling in CD4(+) T cells fail to develop a protective Th2 cell response against the gastrointestinal helminth Trichuris muris. In contrast, they exhibit effective Th1 cell responses and are able to control Leishmania major infection. These data demonstrate that Notch signaling is a regulator of type 2 immunity.
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spelling pubmed-22132102008-03-11 Notch signaling is an important regulator of type 2 immunity Tu, LiLi Fang, Terry C. Artis, David Shestova, Olga Pross, Seth E. Maillard, Ivan Pear, Warren S. J Exp Med Brief Definitive Report Notch ligands and receptors have been implicated in helper T cell (Th cell) differentiation. Whether Notch signals are involved in differentiation of T helper type 1 (Th1) cells, Th2 cells, or both, however, remains unresolved. To clarify the role of Notch in Th cell differentiation, we generated mice that conditionally inactivate Notch signaling in mature T cells. Mice that lack Notch signaling in CD4(+) T cells fail to develop a protective Th2 cell response against the gastrointestinal helminth Trichuris muris. In contrast, they exhibit effective Th1 cell responses and are able to control Leishmania major infection. These data demonstrate that Notch signaling is a regulator of type 2 immunity. The Rockefeller University Press 2005-10-17 /pmc/articles/PMC2213210/ /pubmed/16230473 http://dx.doi.org/10.1084/jem.20050923 Text en Copyright © 2005, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Brief Definitive Report
Tu, LiLi
Fang, Terry C.
Artis, David
Shestova, Olga
Pross, Seth E.
Maillard, Ivan
Pear, Warren S.
Notch signaling is an important regulator of type 2 immunity
title Notch signaling is an important regulator of type 2 immunity
title_full Notch signaling is an important regulator of type 2 immunity
title_fullStr Notch signaling is an important regulator of type 2 immunity
title_full_unstemmed Notch signaling is an important regulator of type 2 immunity
title_short Notch signaling is an important regulator of type 2 immunity
title_sort notch signaling is an important regulator of type 2 immunity
topic Brief Definitive Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213210/
https://www.ncbi.nlm.nih.gov/pubmed/16230473
http://dx.doi.org/10.1084/jem.20050923
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