The Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesis

The Scurfy mutation of the FoxP3 gene (FoxP3 (sf)) in the mouse and analogous mutations in human result in lethal autoimmunity. The mutation of FoxP3 in the hematopoietic cells impairs the development of regulatory T cells. In addition, development of the Scurfy disease also may require mutation of...

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Autores principales: Chang, Xing, Gao, Jian Xin, Jiang, Qi, Wen, Jing, Seifers, Nick, Su, Lishan, Godfrey, Virginia L., Zuo, Tao, Zheng, Pan, Liu, Yang
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213221/
https://www.ncbi.nlm.nih.gov/pubmed/16230479
http://dx.doi.org/10.1084/jem.20050157

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