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The insulin A-chain epitope recognized by human T cells is posttranslationally modified

The autoimmune process that destroys the insulin-producing pancreatic β cells in type 1 diabetes (T1D) is targeted at insulin and its precursor, proinsulin. T cells that recognize the proximal A-chain of human insulin were identified recently in the pancreatic lymph nodes of subjects who had T1D. To...

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Detalles Bibliográficos
Autores principales:	Mannering, Stuart I., Harrison, Leonard C., Williamson, Nicholas A., Morris, Jessica S., Thearle, Daniel J., Jensen, Kent P., Kay, Thomas W.H., Rossjohn, Jamie, Falk, Ben A., Nepom, Gerald T., Purcell, Anthony W.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2005
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213236/ https://www.ncbi.nlm.nih.gov/pubmed/16260488 http://dx.doi.org/10.1084/jem.20051251

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