Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size

Stem cells reside in a specialized niche that regulates their abundance and fate. Components of the niche have generally been defined in terms of cells and signaling pathways. We define a role for a matrix glycoprotein, osteopontin (OPN), as a constraining factor on hematopoietic stem cells within t...

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Detalles Bibliográficos
Autores principales: Stier, Sebastian, Ko, Yon, Forkert, Randolf, Lutz, Christoph, Neuhaus, Thomas, Grünewald, Elisabeth, Cheng, Tao, Dombkowski, David, Calvi, Laura M., Rittling, Susan R., Scadden, David T.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213260/
https://www.ncbi.nlm.nih.gov/pubmed/15928197
http://dx.doi.org/10.1084/jem.20041992

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