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Coordinate Expression and Trans Presentation of Interleukin (IL)-15Rα and IL-15 Supports Natural Killer Cell and Memory CD8(+) T Cell Homeostasis

The high affinity interleukin (IL)-15 receptor, IL-15Rα, is essential for supporting lymphoid homeostasis. To assess whether IL-15Rα's role in vivo is to trans present IL-15, we generated mixed bone marrow chimera from IL-15Rα– and IL-2/15Rβ–deficient mice. We find that IL-15Rα–competent, IL-2/...

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Detalles Bibliográficos
Autores principales:	Burkett, Patrick R., Koka, Rima, Chien, Marcia, Chai, Sophia, Boone, David L., Ma, Averil
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2004
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213280/ https://www.ncbi.nlm.nih.gov/pubmed/15452177 http://dx.doi.org/10.1084/jem.20041389

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